Benign COVID-19 in an immunocompromised cancer patient - the case of a married couple.
Identifieur interne : 000967 ( 2020/Analysis ); précédent : 000966; suivant : 000968Benign COVID-19 in an immunocompromised cancer patient - the case of a married couple.
Auteurs : Valentina Spezzani [Italie] ; Alessio Piunno [Italie] ; Hans-Ulrich Iselin [Suisse]Source :
- Swiss medical weekly [ 1424-3997 ] ; 2020.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Antibactériens (usage thérapeutique), Antiviraux (usage thérapeutique), Cobicistat (usage thérapeutique), Conjoints, Darunavir (usage thérapeutique), Dyspnée (étiologie), Femelle, Fièvre (étiologie), Humains, Hydroxychloroquine (usage thérapeutique), Immunocompétence, Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Mâle, Pandémies, Pneumopathie virale (traitement médicamenteux), Pneumopathie virale (virologie), Récidive tumorale locale (traitement médicamenteux), Résultat thérapeutique, Service hospitalier d'urgences, Soins de réanimation, Sujet immunodéprimé, Tumeurs du sein ().
- MESH :
- traitement médicamenteux : Infections à coronavirus, Pneumopathie virale, Récidive tumorale locale.
- usage thérapeutique : Antibactériens, Antiviraux, Cobicistat, Darunavir, Hydroxychloroquine.
- virologie : Infections à coronavirus, Pneumopathie virale.
- étiologie : Dyspnée, Fièvre.
- Adulte d'âge moyen, Conjoints, Femelle, Humains, Immunocompétence, Mâle, Pandémies, Résultat thérapeutique, Service hospitalier d'urgences, Soins de réanimation, Sujet immunodéprimé, Tumeurs du sein.
English descriptors
- KwdEn :
- Anti-Bacterial Agents (therapeutic use), Antiviral Agents (therapeutic use), Betacoronavirus, Breast Neoplasms (complications), Cobicistat (therapeutic use), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Critical Care, Darunavir (therapeutic use), Dyspnea (etiology), Emergency Service, Hospital, Female, Fever (etiology), Humans, Hydroxychloroquine (therapeutic use), Immunocompetence, Immunocompromised Host, Male, Middle Aged, Neoplasm Recurrence, Local (drug therapy), Pandemics, Pneumonia, Viral (drug therapy), Pneumonia, Viral (virology), Spouses, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Anti-Bacterial Agents, Antiviral Agents, Cobicistat, Darunavir, Hydroxychloroquine.
- complications : Breast Neoplasms.
- drug therapy : Coronavirus Infections, Neoplasm Recurrence, Local, Pneumonia, Viral.
- etiology : Dyspnea, Fever.
- virology : Coronavirus Infections, Pneumonia, Viral.
- Betacoronavirus, Critical Care, Emergency Service, Hospital, Female, Humans, Immunocompetence, Immunocompromised Host, Male, Middle Aged, Pandemics, Spouses, Treatment Outcome.
Abstract
Respiratory failure in COVID-19 is a common feature in fatal cases and has been considered as a failure of the immune system to control the virus. Here we report the case of COVID-19 affecting an immunocompromised women and her presumably immunocompetent spouse. A married couple (age 60 years) was simultaneously admitted to the emergency department on 10 March 2020 because of dyspnoea and fever, consistent with COVID-19. The wife (patient 1) was partially immunocompromised as a consequence of a recently started chemotherapy with fulvestrant and abemaciclid for recurring breast cancer, her husband (patient 2) had been healthy except for a history of controlled arterial hypertension. Both patients were treated with darunavir/cobicistat and hydroxychloroquine. The clinical course of the immunocompromised partner was benign, without need of intensive care. She was able to leave the hospital on day 6 after admission. In contrast, her husband needed intensive care and his recovery was slow, although eventually successful too. These findings suggest that the course of COVID-19 is not necessarily ominous in the presence of a compromised immune response and tend to reinforce the emerging therapeutic concepts of a controlled mitigation of the immune cascade following SARS CoV-2 infection.
DOI: 10.4414/smw.2020.20246
PubMed: 32277836
Affiliations:
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pubmed:32277836Le document en format XML
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(étiologie)</term><term>Femelle</term><term>Fièvre (étiologie)</term><term>Humains</term><term>Hydroxychloroquine (usage thérapeutique)</term><term>Immunocompétence</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Mâle</term><term>Pandémies</term><term>Pneumopathie virale (traitement médicamenteux)</term><term>Pneumopathie virale (virologie)</term><term>Récidive tumorale locale (traitement médicamenteux)</term><term>Résultat thérapeutique</term><term>Service hospitalier d'urgences</term><term>Soins de réanimation</term><term>Sujet immunodéprimé</term><term>Tumeurs du sein ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term><term>Antiviral Agents</term><term>Cobicistat</term><term>Darunavir</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Neoplasm Recurrence, Local</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Dyspnea</term><term>Fever</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Récidive tumorale locale</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antibactériens</term><term>Antiviraux</term><term>Cobicistat</term><term>Darunavir</term><term>Hydroxychloroquine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords 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considered as a failure of the immune system to control the virus. Here we report the case of COVID-19 affecting an immunocompromised women and her presumably immunocompetent spouse. A married couple (age 60 years) was simultaneously admitted to the emergency department on 10 March 2020 because of dyspnoea and fever, consistent with COVID-19. The wife (patient 1) was partially immunocompromised as a consequence of a recently started chemotherapy with fulvestrant and abemaciclid for recurring breast cancer, her husband (patient 2) had been healthy except for a history of controlled arterial hypertension. Both patients were treated with darunavir/cobicistat and hydroxychloroquine. The clinical course of the immunocompromised partner was benign, without need of intensive care. She was able to leave the hospital on day 6 after admission. In contrast, her husband needed intensive care and his recovery was slow, although eventually successful too. These findings suggest that the course of COVID-19 is not necessarily ominous in the presence of a compromised immune response and tend to reinforce the emerging therapeutic concepts of a controlled mitigation of the immune cascade following SARS CoV-2 infection.</div></front></TEI><affiliations><list><country><li>Italie</li><li>Suisse</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Spezzani, Valentina" sort="Spezzani, Valentina" uniqKey="Spezzani V" first="Valentina" last="Spezzani">Valentina Spezzani</name></noRegion><name sortKey="Piunno, Alessio" sort="Piunno, Alessio" uniqKey="Piunno A" first="Alessio" last="Piunno">Alessio Piunno</name></country><country name="Suisse"><noRegion><name sortKey="Iselin, Hans Ulrich" sort="Iselin, Hans Ulrich" uniqKey="Iselin H" first="Hans-Ulrich" last="Iselin">Hans-Ulrich Iselin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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